Ring methyl oxidation and N-deethylation activities toward DEET in human cytochrome P450 isoforms expressed in baculovirus-infected insect cells
| BALC (Ring Methyl Oxidation) | ET (N-Deethylation) | |
|---|---|---|
| nmol/nmol isoform/min | ||
| 1A2 | 68.94 ± 2.64a | Not detected |
| 2B6 | 69.51 ± 1.83a | Not detected |
| 2D6*1 | 56.56 ± 2.52b | Not detected |
| 2E1 | 3.34 ± 0.17c | Not detected |
| 2A6 | Not detected | 4.55 ± 0.30a |
| 2C19 | Not detected | 8.96 ± 0.82b |
| 3A4 | Not detected | 5.05 ± 0.20a |
| 3A5 | Not detected | 5.81 ± 0.24a |
Means in the same column followed by the same letter are not significantly different (P < 0.01). Values are the mean ± S.E.M. (n = 3).