Kinetic parameters for ring methyl oxidation of DEET by human cytochrome P450 isoforms expressed in baculovirus infected insect cells
| BALC (Ring Methyl Oxidation) | |||
|---|---|---|---|
| Km | Vmax | CLint | |
| μM | nmol/nmol isoform/min | 10−6/nmol isoform/min | |
| CYP2B6 | 40.2 ± 1.2a | 22.3 ± 2.1a | 552.0 ± 40.4a |
| CYP1A2 | 41.0 ± 2.0a | 24.5 ± 1.2a | 598.7 ± 39.6a |
| CYP2D6 | >1000 | ||
Means in the same column followed by the same letter are not significantly different (P < 0.01). Values are the mean ± S.E.M. (n = 3).