Inhibitor | Substrate | ||
---|---|---|---|
TCA | Digoxin | E217βG | |
μM | |||
TCA | K m = 187 ± 46 | K i = 156 ± 23 | K i = 39.4 ± 22.5 |
Digoxin | K i = 0.58 ± 0.27 | K m = 1.07 ± 0.18 | K i = 0.037 ± 0.029 |
E217βG | —1-a | —1-b | K m= 17.0 ± 5.5 |
Data are taken from Fig. 2, 3, and Sugiyama et al. (2001). These Km and Kivalues were determined by nonlinear regression analysis. Each point represents the mean ± S.E. (n = 3).