Inhibitor | Substrate | ||
---|---|---|---|
TCA | Digoxin | E_{2}17βG | |
μM | |||
TCA | K _{m} = 187 ± 46 | K _{i} = 156 ± 23 | K _{i} = 39.4 ± 22.5 |
Digoxin | K _{i} = 0.58 ± 0.27 | K _{m} = 1.07 ± 0.18 | K _{i} = 0.037 ± 0.029 |
E_{2}17βG | —^{1-a} | —^{1-b} | K _{m}= 17.0 ± 5.5 |
Data are taken from Fig. 2, 3, and Sugiyama et al. (2001). These K_{m} and K_{i}values were determined by nonlinear regression analysis. Each point represents the mean ± S.E. (n = 3).