Sample | KM | Vmax | CLint (Vmax/KM) |
---|---|---|---|
μM | pmol/min/mg | μl/min/mg | |
Human Liver Microsomes | |||
HLC | 2.3 ± 0.11-a | 115 ± 2 | 50 |
HLM | 2.2 ± 0.1 | 340 ± 6 | 155 |
HLK1-b | 153 ± 13 | 17 ± 1 | 0.1 |
HLN1-b | 144 ± 9 | 37 ± 1 | 0.3 |
Expressed P450s | |||
CYP1A2 | 399 ± 40 | 4.6 ± 1.2 | N.D.1-c |
CYP2B6 | 29 ± 1 | 2.6 ± 0.1 | N.D. |
CYP2C19 | 96 ± 7 | 3.0 ± 0.1 | N.D. |
CYP2E1 | 5.0 ± 0.9 | 2.1 ± 0.1 | N.D. |