Table 2

4-Hydroxyatomoxetine or N-desmethylatomoxetine formation rates (picomoles per minute per milligram) by a bank of human liver microsomal samples^2-a

Sample	4-Hydroxyatomoxetine following Incubation with 1 μM Atomoxetine	4-Hydroxyatomoxetine following Incubation with 100 μM Atomoxetine and 10 μM Quinidine	N-Desmethylatomoxetine following Incubation with 10 μM Atomoxetine
HLA	23.5	19.3	9.4
HLB	104.9	22.1	4.9
HLC	45.7	21.0	7.9
HLD	165.1	28.5	6.2
HLE	104.1	65.5	22.5
HLF	70.4	27.2	4.6
HLG	127.4	41.4	7.1
HLH	53.0	21.8	5.7
HLI	77.3	33.2	8.6
HLJ	61.7	34.1	10.3
HLK	0^2-b	9.1	6.0
HLL	29.0	12.8	0^2-b
HLM	145.1	22.9	6.74
HLN	0^2-b	13.5	11.5
HLO	131.4	41.4	13.3
HLP	76.0	20.1	8.8
HLQ	129.7	38.1	5.1
HLR	34.3	13.7	5.8
HLS	59.4	41.9	14.8
HLT	44.8	30.1	9.2

↵2-a Assays were performed as described under Materials and Methods.
↵2-b Below quantifiable limit of assay. For the purpose of correlation analysis, the rate of formation in these livers was assumed to be zero.