Tissues/Fluids | Treated Eye | Untreated Eye | ||||
---|---|---|---|---|---|---|
Tmax | Cmax | t1/2* | Tmax | Cmax | t1/2* | |
h | μg-Eq/g or ml | days | h | μg-Eq/g or ml | h | |
Tear | 0.17 | 195.0 | N.D. | 24.0 | 0.00434 | N.D. |
Lower bulbar conjunctiva | 0.17 | 12.9 | 9.17 | 1.5 | 0.0145 | N.D. |
Upper bulbar conjunctiva | 0.17 | 12.9 | 8.04 | 1.5 | 0.011 | N.D. |
Cornea | 0.17 | 11.5 | 13.3 | 1.5 | 0.00976 | N.D. |
Aqueous humor | 1.5 | 1.26 | 3.06 | 3.0 | 0.000763 | N.D. |
Iris | 1.5 | 53.8 | 17.3 | 6.0 | 0.332 | 10.9 |
Ciliary body | 1.5 | 19.1 | 19.5 | 6.0 | 0.445 | 13.1 |
Lens | 1.5 | 0.107 | N.D. | 1.5 | 0.000247 | N.D. |
Vitreous humor | 0.17 | 0.0493 | 10.4 | 3.0 | 0.00201 | N.D. |
Choroid/retina | 1.5 | 3.22 | 37.2 | 3.0 | 0.124 | N.D. |
Blood | 1.5 | 0.00789 | N.D. |
Terminal half-lives of radioactivity were calculated over the time intervals of 1 to 15 days for aqueous humor, 15 to 30 days for conjunctiva, and 15 to 60 days for cornea, sclera, iris, ciliary body, vitreous humor, choroid/retina, and optic nerve head.
N.D., half-life was not determined due to insufficient data in the terminal phase.