C
max(μg/ml)1-a
| 27.3 ± 15.4 | 159.0 ± 42.9 | 31.0 ± 32.9 | 60.7 ± 11.2 | 89.9 ± 16.1 |
C
5min(μg/ml)1-b
| 12.1 ± 6.4 | 126.6 ± 17.4 | 14.0 ± 5.4 | 54.7 ± 11.8 | 84.6 ± 10.9 |
α (hr−1) | 10.72 ± 5.06 | 4.7 ± 2.95 | 10.45 ± 6.44 | 1.19 ± 0.81 | 2.99 ± 2.09 |
t
1/2α(h)1-c
| 0.07 | 0.14 | 0.07 | 0.58 | 0.23 |
| (0.04–0.14) | (0.09–1.22) | (0.04–0.13) | (0.29–6.03) | (0.15–1.75) |
β (h−1) | 0.271 ± 0.099 | 0.029 ± 0.008 | 0.164 ± 0.108 | 0.028 ± 0.009 | 0.030 ± 0.005 |
t
1/2β(h)1-c
| 2.6 | 24.3 | 4.2 | 24.7 | 23.0 |
| (1.74–4.56) | (16.85–33.48) | (2.27–18.02) | (16.06–37.65) | (19.27–28.90) |
Vdss (ml) | 1214 ± 433.7 | N.A. | 2941 ± 2261 | N.A. | 59.64 ± 5.41 |
MRT (h) | 2.16 ± 0.96 | 35.55 ± 8.92 | 7.58 ± 9.85 | 35.52 ± 8.0 | 33.54 ± 6.34 |
AUC0–72h(μg · h/ml)1-d
| 6.49 ± 3.33 | 2202 ± 403.2 | 20.96 ± 0.63 | 1175 ± 483.3 | 1372 ± 235.9 |
AUC0–∞(μg · h/ml)1-d
| 7.18 ± 3.56 | 2706 ± 577.4 | 23.02 ± 33.21 | 1384 ± 611.7 | 1578 ± 346.6 |
CL (ml/h) | 452.6 ± 161.2 | 2.00 ± 2.121-e
| 385.5 ± 72.3 | 2.30 ± 1.691-e
| 1.79 ± 0.39 |
f
R
1-f
| | | 0.93 |
72 hr Urinary excretion (% of dose) | 6.69 ± 0.96 | 9.87 ± 2.02 | 7.36 ± 2.19 |
72 hr Fecal elimination (% of dose) | 7.2 ± 2.4 | 8.8 ± 6.4 | 8.4 ± 6.1 |