Tissue | mdr1a/1b(+/+) | mdr1a/1b(−/−) | (−/−)/(+/+) | mdr1a/1b(+/+) | mdr1a/1b(−/−) | (−/−)/(+/+) |
---|---|---|---|---|---|---|
μg/g tissue | tissue/plasma | |||||
Plasma | 4.95 ± 0.46 | 5.28 ± 1.03 | 1.07 | |||
Brain | 2.01 ± 0.51 | 2.73 ± 0.29 | 1.36 | 0.41 ± 0.11 | 0.52 ± 0.05 | 1.28 |
Heart | 4.10 ± 0.92 | 4.55 ± 0.62 | 1.11 | 0.82 ± 0.11 | 0.86 ± 0.05 | 1.05 |
Lungs | 5.12 ± 0.34 | 7.11 ± 0.22 | 1.39 | 1.04 ± 0.05 | 1.38 ± 0.31 | 1.33 |
Liver | 21.20 ± 6.38 | 25.51 ± 0.83 | 1.20 | 4.23 ± 0.98 | 4.91 ± 0.80 | 1.16 |
Spleen | 6.12 ± 0.94 | 10.50 ± 4.57 | 1.71 | 1.23 ± 0.10 | 2.11 ± 1.28 | 1.71 |
Kidney | 7.89 ± 0.11 | 7.78 ± 0.36 | 0.99 | 1.60 ± 0.16 | 1.49 ± 0.22 | 0.93 |
Small intestine | 9.31 ± 2.83 | 12.03 ± 4.71 | 1.29 | 1.91 ± 0.73 | 2.23 ± 0.45 | 1.16 |
Colon | 5.30 ± 0.63 | 5.27 ± 0.10 | 0.99 | 1.08 ± 0.18 | 1.01 ± 0.18 | 0.94 |
Testis | 2.36 ± 0.19 | 2.35 ± 0.13 | 1.00 | 0.48 ± 0.06 | 0.45 ± 0.06 | 0.94 |
Data are shown as mean ± S.D. Statistical difference between the two groups of mice (three per group) was assessed by a two-sided Student's test, with P < 0.05 as the limit of significance.