Table 1

Overall metabolism and kinetic parameters of individual biotransformation reactions of taxoids by human liver microsomes

Taxoids	Overall Metabolism	Metabolite	Rate of Formation	K_m	V_m	V_m/K_m
	%		%	μM	pmol/min/nmolP450
Paclitaxel	4	C6	63	15	1950	130
		3′-phenyl	37	15	530	35
Deacetylpaclitaxel	0.8	C6	72	200	3000	15
		2-Benzoyl	28	67	1200	18
Acetyldocetaxel	2.1	C6	26	50	1980	40
		3′-Phenyl	53	4	1200	300
		t-Butyl	21	7	400	57
Docetaxel	1.2	t-Butyl	100	2	800	400
Baccatin III	0.7	N.D.	79	35	1920	55
		N.D.	21	200	900	4.5
Deacetylbaccatin III	0.36	N.D.	100	27	575	21.3