Table 1

Coefficients calculated from multivariable linear regression analysis of the peak versus area relationship between hydrolyzed and original perfusate of genistein and its analogs

Compound	Hydrolyzed Peak	Original Peak	Regression Equation	Average δ
Genistein	Genistein ABS_total	ABS_genistein ABS_metabolite1ABS_metabolite2	ABS_total = ABS_genistein ⁺ 0.716 ABS_metabolite1 ⁺ 0.890 ABS_metabolite2	2.54 ± 2.38%
Genistin	Genistin ABS_total	ABS_genistin ABS_metabolite1 ABS_metabolite2	ABS_total= ABS_genistin ⁺ 1.783 ABS_metabolite2 ⁺ 0.822 ABS_metabolite1	3.15 ± 2.01%
Apigenin	Apigenin ABS_apigenin	ABS_apigenin ABS_metabolites	ABS_total= ABS_apigenin ⁺ 0.732 ABS_metabolites	1.7 ± 1.5%
Apigetrin	Apigetrin ABS_total	ABS_apigetrin ABS_metabolite1 ABS_metabolite2	ABS_total= ABS_apigetrin ⁺ 1.410 ABS_metabolite1 ⁺ 0.584 ABS_metabolite2	1.11 ± 0.58%

The average δ is the average of 16 determinations using four rats at four time points each.