Percentages of drugs metabolized into acyl glucuronide and of acyl glucuronide isomerized between the biosynthesis phase and the reactivity phase
| Compound Name | Acyl Glucuronide Formed | Isomerisation |
|---|---|---|
| % | ||
| Tolmetin | 5.6 ± 4.8 | 92.8 ± 18.1 |
| Zomepirac | 22.5 ± 10.5 | 42.4 ± 20.4 |
| Suprofen | 68.6 ± 2.1 | 32.0 ± 8.3 |
| Diclofenac | 89.4 ± 0.5 | 72.2 ± 3.4 |
| Fenoprofen | 55.8 ± 0.4 | 51.0 ± 12.2 |
| Ibuprofen | 53.3 ± 6.0 | 30.6 ± 8.5 |
| Ketoprofen | 62.8 ± 5.4 | 32.4 ± 4.9 |
| Furosemide | 19.2 ± 2.9 | 0.0 ± 0.0 |
Mean ± S.D. (n = 3); The percentage of acyl glucuronides formed is determined by parent drug depletion. The isomerization percentage was defined as the amount of the 1-O-acyl glucuronide transformed into isomers during the process between the two phases.