The plasma and brain parenchyma concentrations of 6-Cl-ddP, ddI, and nelfinavir after 6-Cl-ddP, nelfinavir, and GF120918 administrations (mean ± S.D.; n = 3)
| Dose | 6-Cl in Plasma | 6-Cl in Brain Parenchyma | ddI in Plasma | ddI in Brain Parenchyma | Nelf in Plasma | Nelf in Brain Parenchyma |
|---|---|---|---|---|---|---|
| μg/ml | μg/g | μg/ml | μg/g | μg/ml | μg/g | |
| 6-Cl | 14.7 ± 6.0 | 5.5 ± 2.3 | 11.6 ± 0.8 | 6.2 ± 0.2 | ||
| (17.2 ± 3.6) | (11.6 ± 4.6) | (7.9 ± 1.8) | (6.4 ± 1.7) | |||
| 6-Cl + Nelf | 18.8 ± 10.4 | 7.3 ± 2.2 | 12.3 ± 1.2 | 5.3 ± 0.8 | 15.9 ± 4.4 | 0.2 ± 0.2 |
| 6-Cl +918 | 22.6 ± 9.8 | 10.9 ± 0.8 | 13.9 ± 3.1 | 7.9 ± 0.21-a 1-b | ||
| Nelf | 12.5 ± 1.2 | 0.3 ± 0.2 | ||||
| Nelf +918 | 12.3 ± 2.5 | 23.2 ± 2.61-b 1-d | ||||
| 6-Cl + Nelf +918 | 25.4 ± 10.3 | 11.0 ± 4.5 | 20.2 ± 3.01-a 1-b 1-c | 12.2 ± 0.31-a 1-b 1-c | 14.4 ± 5.8 | 16.0 ± 4.91-b 1-d 1-e |
Values in parenthesis are from Morgan et al. (1992).
6-Cl, 6-Cl-ddP; Nelf, nelfinavir; 918, GF120918.
↵1-a Values are significantly different from 6-Cl.
↵1-b Values are significantly different from 6-Cl + Nelf.
↵1-c Values are significantly different from 6-Cl + 918.
↵1-d Values are significantly different from Nelf.
↵1-e Values are significantly different from Nelf + 918 (p < 0.05, Two-way analysis of variance and Tukey's post hoc test).