Table 2

Apparent first-order degradation of various acyl glucuronides and aglycone appearance constants measured during incubation phases with 0.5 mM HSA, pH 7.4, at 37°C

Compound Name	Acyl Glucuronide Degradation Rate	Aglycone Appearance Rate
	h⁻¹
Tolmetin	0.055 ± 0.020	0.106 ± 0.049
Zomepirac	0.025 ± 0.008	0.103 ± 0.027
Suprofen	0.046 ± 0.021	0.035 ± 0.018
Diclofenac	0.050 ± 0.016	0.081 ± 0.023
Fenoprofen	0.021 ± 0.014	0.044 ± 0.011
Ibuprofen	0.028 ± 0.003	0.037 ± 0.013
Ketoprofen	0.037 ± 0.010	0.016 ± 0.005
Furosemide	0.006 ± 0.011	0.000 ± 0.001

Mean ± S.D. (n = 3).