Kinetic parameters for UDPGA-dependent metabolism of statins in liver microsomal preparations
| Statin | Species | Km | Vmax | CLint |
|---|---|---|---|---|
| μM | pmol/min/mg | μl/min/mg | ||
| SVA | Human | 416 ± 802-a | 162 ± 23 | 0.4 |
| Dog | 19 ± 8 | 263 ± 28 | 13.8 | |
| Rat | 35 ± 4 | 57 ± 2 | 1.6 | |
| AVA | Human | 16 ± 4 | 52 ± 3 | 3.3 |
| Dog | 13 ± 2 | 69 ± 3 | 5.3 | |
| Rat | 16 ± 3 | 24 ± 1 | 1.5 | |
| CVA | Human | 83 ± 4 | 238 ± 4 | 2.9 |
| Dog | 92 ± 15 | 184 ± 13 | 2.0 | |
| Rat | 90 ± 6 | 278 ± 8 | 3.1 |
Incubations were performed in duplicate for each substrate concentration using pooled liver microsomes from humans (n = 20), dogs (n = 4), and rats (n = 6). Values are estimates ± S.E.
↵2-a Extrapolated values.