Table 3

Effects of established enzyme inducers on the glucuronidation and sulfation of chrysin in intact Hep G2 cells

Inducer	Concentration	References	Glucuronidation	Sulfation
	μM		% of control
t-Butylhydroquinone	50	Münzel et al. (1999)	122 ± 24	117 ± 9
Dexamethasone	1	Doostdar et al. (1993),	88 ± 4	91 ± 6
		Donato et al. (1995)
3-Methylcholanthrene	1	Donato et al. (1995),	200 ± 40^3-a	116 ± 2
		Chung and Bresnick (1994),
		Ritter et al. (1999),
		Runge et al. (2000)
β-Naphthoflavone	50	Runge et al. (2000),	96 ± 10	97 ± 8
		Abid et al. (1995)
Oltipraz	50	Ritter et al. 1999	187 ± 18^3-a	82 ± 6
Phenobarbital	2000	Doostdar et al. (1993),	98 ± 9	69 ± 5
		Donato et al. (1995),
		Ritter et al. (1999),
		Runge et al. (2000)
TCDD	0.01	Bock et al. (1999),	99 ± 17	99 ± 7
		Münzel et al. (1999)

The cells were treated for 1 (TCDD) or 3 days with vehicle or potential inducer and the formation of chrysin glucuronide and sulfate was measured by HPLC in the medium after a 6-h incubation of the cells with chrysin.

↵3-a Significantly higher than control; P < 0.05.