Protein | Dextromethorphan | Bufuralol | Debrisoquine | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Km | Vmax | Vmax/Km | Vmax/Km | Km | Vmax | VmaxKm | Vmax/Km | Km | Vmax | Vmax/Km | Vmax/Km | |
μM | pmol/pmol/min | μl/min/nmol | % CYP2D6.1 | μM | pmol/pmol/min | μl/min/nmol | % CYP2D6.1 | μM | pmol/pmol/min | μl/min/nmol | % CYP2D6.1 | |
CYP2D6.1 | 1.0 ± 0.3 | 2.4 ± 0.4 | 2400 ± 273 | 8.1 ± 0.9 | 10.2 ± 0.7 | 1259 ± 287 | 13.4 ± 3.3 | 2.8 ± 0.1 | 209 ± 43 | |||
CYP2D6.2 | 1.4 ± 0.3 | 3.7 ± 0.4 | 2600 ± 457 | 109 | 13.0 ± 1.7 | 19.3 ± 0.5 | 1485 ± 186 | 117 | 21.2 ± 0.1 | 4.5 ± 0.0 | 212 ± 0.0 | 101 |
CYP2D6.17 | 6.1 ± 0.6 | 2.7 ± 0.4 | 450 ± 38 | 18 | 16.5 ± 0.4 | 4.5 ± 0.0 | 273 ± 6 | 22 | 46.3 ± 2.5 | 2.2 ± 2.5 | 47 ± 1.0 | 22 |