Relative sensitivity of predicted methemoglobin accumulation to parameter variations 100 min after oral administration of 40 and 80 mg NaNO2/kg body weight to Fischer 344 rats
| Parameter | Male | Female |
|---|---|---|
| 40 mg/kg | ||
| P | 1.06 | 0.853 |
| ka | 0.352 | 0.350 |
| ke | −1.06 | −0.871 |
| Km | 0.572 | 0.439 |
| k1 | 0.965 | 0.902 |
| 80 mg/kg | ||
| P | 1.01 | 0.734 |
| ka | 0.413 | 0.354 |
| ke | −1.03 | −0.765 |
| Km | 0.401 | 0.258 |
| k1 | 0.955 | 0.784 |