Parameter | Dextromethorphan O-Demethylation (CYP2D6) | Testosterone 6β-Hydroxylation (CYP3A4) | Aflatoxin B1 3-Hydroxylation (CYP3A4) |
---|---|---|---|
KS (μM) | 7.75 (0.67) | 30.43 (1.89) | 234.7 (34.2) |
Vmax (nmol/min/nmol) | 17.51 (0.47) | 43.82 (0.92) | 64.00 (4.73) |
KI (μM) | 0.24 (0.05) | 0.05 (0.01) | 0.10 (0.13) |
α2-a | 0.99 (0.25) | 0.41 (0.12) | 0.48 (0.13) |
β2-a | 0.05 (0.01) | 0.06 (0.00) | 0.06 (0.01) |
RSS | 8.13 | 16.67 | 42.93 |
R 2 | 0.988 | 0.996 | 0.985 |
↵2-a α and β represent changes in Km and Vmax in the absence of the MAb.