Table 1

Pharmacokinetic parameters determined from total radioactivity, and rofecoxib plasma concentrations from healthy subjects and cholecystectomy patients following oral administration of [¹⁴C]rofecoxib

	Healthy Subjects (n = 6)		Cholecystectomy Patients (n = 4)
	Radioactivity^1-a	Rofecoxib	Radioactivity	Rofecoxib
Dose, mg/kg		3.31 (0.18)		1.91 (0.27)
AUC, μg-eq · h/ml	35.0 (5.0)^1-b	22.0 (3.8)	18.5 (8.1)	5.9 (2.1)
C _max, μg-eq/ml	1.1 (0.4)	0.8 (0.3)	0.4 (0.1)	0.2 (0.1)
t _max,^1-ch	9.0	9.0	10.0	8.0

↵1-a Values represent total radioactivity (rofecoxib and metabolites).
↵1-b Values in parentheses are standard deviations.
↵1-c Median.