Effect of licorice root extract on the activity of P450 3A4
| Licorice Root Extract | % Activity Remaining | |
|---|---|---|
| 0 min | 15 min | |
| μg/ml | ||
| 0 | 100 | 103 ± 1 |
| 1.4 | 110 ± 7 | 73 ± 2 |
| 6.9 | 110 ± 1 | 45 ± 1 |
| 14 | 79 ± 2 | 25 ± 1 |
| 69 | 40 ± 3 | 12 ± 2 |
P450 3A4 was reconstituted with reductase and lipid, incubated with licorice root extract, and evaluated for 7BFC activity as described under Experimental Procedures. The data shown represents the averages and ranges from duplicate samples.