Liver Donor Identification | Sex | Age (yr) | Race | Diagnosis | Death |
---|---|---|---|---|---|
HL-N0951-a | M | 63 | white | Cerebrovascular stroke | Yes |
HL-N098 | M | 56 | white | Head trauma | Yes |
HL-N100 | M | 57 | white | Not known | No |
H2321-150 | M | 43 | white | Hypertensive bleed | Yes |
H233 | M | 6 | white | Head trauma | Yes |
H249 | F | 33 | white | Carbon monoxide poisoning | Yes |
H254 | F | 72 | white | Hepatocellular carcinoma | No |
↵1-150 Human hepatocytes from each of the donors were used to test all 14 test compounds, except for donors H232 and H233. Hepatocytes from donor H232 were used for dexamethasone, dexamethasone-t-butylacetate, methotrexate, and phenobarbital, whereas those from donor H233 were used for the remaining 10 compounds.
↵1-a Primary cell cultures of human hepatocytes were performed at University of North Carolina at Chapel Hill for donors HL-N095, HL-N098, and HL-N100 and at XenoTech LLC. for donors H232, H233, H249, and H254.