Time | Total Radioactivity | ||||
---|---|---|---|---|---|
Subject 1 | Subject 2 | Subject 3 | Subject 4 | Mean ± S.D. | |
h | ng-Eq/ml | ||||
0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 ± 0.0 |
1 | 116.4 | 211.9 | 259.3 | 145.1 | 183.2 ± 64.7 |
2 | 267.9 | 444.6 | 433.9 | 571.2 | 425.9 ± 130.5 |
3 | 243.2 | 508.5 | 364.8 | 490.0 | 407.8 ± 113.1 |
4 | 137.7 | 468.9 | 327.8 | 553.3 | 398.3 ± 139.1 |
6 | 98.8 | 406.2 | 202.3 | 287.4 | 258.4 ± 116.0 |
8 | 12.7 | 319.2 | 141.5 | 220.9 | 195.1 ± 97.0 |
24 | 11.0 | 80.7 | 29.5 | 40.6 | 40.9 ± 28.9 |
32 | 3.4 | 38.8 | 23.1 | 20.9 | 23.5 ± 11.5 |
48 | N.Q. | 28.3 | 8.8 | 11.3 | 13.02-a ± 10.82-a |
72 | N.Q. | 4.1 | 2.6 | 6.7 | 4.52-a ± 2.12-a |
96 | N.Q. | 1.2 | 0.5 | 2.9 | 1.52-a ± 1.22-a |
168 | N.Q. | 1.2 | N.Q. | N.Q. | <1.2 median |
C max(ng/ml) | 267.9 | 508.5 | 433.9 | 571.2 | 445.4 ± 131.0 |
T max (h) | 3 | 3 | 2 | 2 | 2.5 ± 0.6 |
T 1/2(h) | 12.1 | 12.0 | 12.0 | 20.5 | 14.1 ± 4.2 |
r 2 | 0.9464 | 0.9811 | 0.9930 | 0.9669 | 0.9718 ± 0.0200 |
AUC0–24(ng · h/ml) | 2270 | 6199 | 3464 | 4925 | 4214 ± 1712 |
AUC0– t(ng · h/ml) | 2480 | 6677 | 4102 | 5758 | 4754 ± 1853 |
AUC0–inf(ng · h/ml) | 2539 | 7779 | 4110 | 5843 | 5068 ± 2256 |
N.Q. Not quantifiable.
↵2-a Calculated on the basis of three values.