Table 1

Examples of drugs that demonstrate supraproportional dose-exposure relationships in humans proposed to be due to saturation of metabolism

DrugIndicationReference
CyclophosphamideAnticancer Chen, et al., 1997
5-FluorouracilAnticancer Hidalgo, et al., 2000
FluoxetineAntidepressant Lane, et al., 1995
FluvoxamineAntidepressant Spigset, et al., 1998
HydralazineAntihypertensive Shepherd, et al., 1984
IndinavirAntiviral Yeh, et al., 1999
MethylenedioxymethamphetamineDrug of abuse de la Torre, et al., 2000
NefazodoneAntidepressant Kaul, et al., 1995
ParoxetineAntidepressant Sindrup, et al., 1992
PropafenoneAntiarrhythmic Siddoway, et al., 1987
Propranololβ-Blocker Silber, et al., 1983
TheophyllineAntiasthma Tang-Liu, et al., 1982
ThiopentalAnaesthetic Russo, et al., 1996
ThioridazineAntipsychotic Chakraborty, et al., 1989