Table 2

Disposition of 3H-labeled 1 in bile duct-cannulated rats

i.v. Dose (3 mg/kg)2-aOral Dose (10 mg/kg)
% of dose recovered
Bile0–120 h:63 ± 1322 ± 9
Urine0–120 h:11 ± 26 ± 3
Feces0–120 h:9 ± 375 ± 20
Total:0–120 h:83 ± 8103 ± 26

Values represent mean ± S.D.

  • 2-a N = 3 rats/dose