Thiol | Drug | k2 |
---|---|---|
M−1 s−1 | ||
GSH | 4OOH-CP | 38 ± 5 |
GSH | acrolein | 490 ± 100 |
mesna | 4OOH-CP | 25 ± 5 |
mesna | acrolein | 700 ± 150 |
WR-1065 | 4OOH-CP | 880 ± 50 |
WR-1065 | acrolein | >2000 |
The k2 values were calculated as described underMaterials and Methods and shown in Fig. 2 to 3.