Table 1

Hepatobiliary disposition of APAP, AG, and AS in isolated single-pass perfused rat livers at steady-state

	Wistar	TR⁻
Excretion rate (pmol/min)
R_{bile_AG}	174 ± 11	0.34 ± 0.02^1-150
R_{bile_AS}	37 ± 2	11 ± 1^1-150
R_{B/L_AG}	175 ± 61	428 ± 18^1-150
R_{B/L_AS}	909 ± 85	1039 ± 6
Biotransformation
ER of APAP	0.30 ± 0.02	0.30 ± 0.02
AG %	12.1 ± 3.3	14.3 ± 0.9
AS %	32.3 ± 2.1	35.2 ± 3.5
Concentration in liver (mM)
C_{liver_AG}	0.613 ± 0.066	0.415 ± 0.028^1-150
C_{liver_AS}	0.356 ± 0.056	0.526 ± 0.110^1-150
Clearance (μl/min)
CL_{bile_AG}	285 ± 37	1.67 ± 0.21^1-150
CL_{bile_AS}	106 ± 12	16 ± 1^1-150
CL_{B/L_AG}	289 ± 107	2110 ± 359^1-150
CL_{B/L_AS} ^1-b	2575 ± 260	1510 ± 130^1-150

R_{bile_AG} and R_{bile_AS} are biliary excretion rates for AG and AS, respectively; R_{B/L_AG}and R_{B/L_AS} are basolateral export rates for AG and AS, respectively; ER is the extraction ratio; AG% and AS% are the percentages of the dose recovered as AG and AS, respectively; C_{liver_AG} and C_{liver_AS} are the AG and AS concentrations at the end of perfusion. CL_{bile_AG}, CL_{bile_AS}, and CL_{B/L_AG} are AG biliary clearance, AS biliary clearance, and AG basolateral clearance, respectively.^1-a

↵1-a Mean ± S.D.,n = 3 for each group.
↵1-b Apparent as basolateral clearance.
↵1-150 P < 0.01, control vs. TR⁻.