Rat | Human | |||||
---|---|---|---|---|---|---|
2D1 | 2D2 | 2D3 | 2D4 | 2D6 | ||
4-Hydroxylation | K m | 186 ± 9 | 6.87 ± 0.62 | N.C. | N.C. | 13.0 ± 1.1 |
V max | 0.23 ± 0.03 | 9.50 ± 0.65 | N.C. | N.C. | 5.15 ± 0.26 | |
3-Hydroxylation | K m | 152 ± 7 | 13.1 ± 1.0 | N.C. | N.C. | 17.0 ± 1.1 |
V max | 4.17 ± 0.25 | 2.84 ± 0.30 | N.C. | N.C. | 6.07 ± 0.61 |
Km and Vmax values are expressed in μM and nmol/min/nmol of P450, respectively. The values are expressed as the mean ± S.D. of three determinations.
N.C., not calculated.