Table 1

Apparent kinetic parameters of STs for troglitazone

KmVmaxSpecificity Constant
μM nmol/nmol/min Vmax/Km
ST1A35.40  ± 0.230.83  ± 0.021.5  × 10−1
ST1B217.00  ± 0.590.27  ± 0.021.6  × 10−2
ST1E48.50  ± 0.441.80  ± 0.332.1  × 10−1
ST2A328.00  ± 0.530.08  ± 0.002.8  × 10−3

Km and Vmax values were derived from analysis of Lineweaver-Burk plots and are shown as the mean ± S.D. of three separate experiments.