TABLE 1

Binding parameter estimates for human, rat, and mouse plasma obtained with a single saturable binding process model a

Species
P b
Binding Parameter Estimates
N
Bmax
Kd
μM μM
Human 239 2.97 708.9 174.6
Rat 190 1.49 283.3 383.6
Mouse
196
0.17
28.7
46.1

  • ↵ a Cbound = (N·P)·Cfree/Cfree·Kd

  • ↵ b P, plasma albumin concentration