Simulations performed for Scheme A
Cases 5 to 13 were used for simulation of the time course of metabolite formation.
Simulation Conditions/Patterns | ka | CLint,met | CLint,sec | CLd1 | CLd2 | fap | fcell | fbaso | ||
|---|---|---|---|---|---|---|---|---|---|---|
| min -1 | ml/min | |||||||||
| Case 1 | 0.01 | 0 to 1 | 0 to 10 | 50 | 50 | 1 | 1 | 1 | ||
| Case 2 | 0.01 | 0 to 1 | 0 to 10 | 5 | 5 | 1 | 1 | 1 | ||
| Case 3 | 0.01 | 0 to 1 | 0 to 10 | 0.01 | 5 | 1 | 1 | 1 | ||
| Case 4 | 0.01 | 0 to 1 | 0 to 10 | 5 | 0.01 | 1 | 1 | 1 | ||
| Case 5 | 0.01 to 0.5 | 1 | 5 | 50 | 50 | 1 | 1 | 1 | ||
| Case 6 | 0.01 | 0.1 to 1 | 5 | 50 | 50 | 1 | 1 | 1 | ||
| Case 7 | 0.01 | 1 | 0 to 10 | 50 | 50 | 1 | 1 | 1 | ||
| Case 8 | 0.01 | 1 | 5 | 50 | 0.01 to 50 | 1 | 1 | 1 | ||
| Case 9 | 0.01 | 1 | 5 | 0.01 to 50 | 50 | 1 | 1 | 1 | ||
| Cases 10-13 | 0.01 | 1 | 5 | 50 | 50 | 0.01 to 1 | ||||