TABLE 4
Comparison of regioselective metabolism of lansoprazole, omeprazole, and its analog H259/31
Clint values estimated from the incubation study of cDNA-expressed CYP3A4 and CYP2C19 were compared between PPI enantiomers. Each arrow indicates the favored hydroxylation site of PPI, which is mediated by CYP2C19.
