Effects of troleandomycin on pharmacokinetic data (mean ± S.D.) of citalopram and desmethylcitalopram in 13 Chinese subjects
n | TAO | Citalopram | Desmethylcitalopram | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AUC0→∞ | Cmax | t½ | CLoral | AUC0→∞ | Cmax | tmax | |||||||
| μg · h/l | nM | h | l/h/kg | μg · h/l | nM | h | |||||||
| Total | -TAO | 1836.6 ± 133.7 | 62.8 ± 7.0 | 36.3 ± 2.4 | 0.36 ± 0.11 | 755.7 ± 47.4 | 8.0 ± 0.8 | 28.0 ± 9.9 | |||||
| TAO | 2098.9 ± 133.7 | 65.5 ± 8.0 | 42.5 ± 2.4 | 0.31 ± 0.13 | 675.5 ± 47.4 | 9.6 ± 3.7 | 22.0 ± 4.8 | ||||||
| PM | -TAO | 2132.5 ± 242.3 | 68.3 ± 16.6 | 39.1 ± 5.5 | 0.31 ± 0.03 | 516.7 ± 58.8 | 6.1 ± 0.8 | 26.0 ± 11.6 | |||||
| TAO | 2728.8 ± 121.9* | 65.5 ± 12.6 | 56.2 ± 4.3 | 0.24 ± 0.04 | 264.9 ± 12.5* | 6.2 ± 0.8 | 24.0 ± 5.4 | ||||||
| EM | -TAO | 1738.0 ± 166.2 | 59.9 ± 5.9 | 35.6 ± 2.5 | 0.39 ± 0.04 | 855.4 ± 59.9 | 9.9 ± 0.9 | 22.2 ± 7.8 | |||||
|
| TAO | 1831.4 ± 155.7 | 64.8 ± 7.4 | 41.6 ± 2.0 | 0.36 ± 0.14 | 866.0 ± 77.1 | 12 ± 0.9 | 21.0 ± 4.4 | |||||
↵* P < 0.05, compared group TAO with group without TAO