P450 Form | Reaction | Test Article | IC50 | ||
---|---|---|---|---|---|
1 | 2 | ||||
μM | |||||
CYP1A2 | Phenacetin O-deethylation | Fluvoxamine | 0.4 | 0.4 | |
Zileuton | >100 | >100 | |||
CYP2C8 | Paclitaxel 6α-hydroxylation | Quercetin | 3.5 | 4.8 | |
Zileuton | >100 | >100 | |||
CYP2C9 | Diclofenac 4′-hydroxylation | Sulfaphenazole | 0.5 | 0.5 | |
Zileuton | >100 | >100 | |||
CYP2C19 | (S)-Mephenytoin 4′-hydroxylation | (R)-N-3-Benzylphenobarbital | 0.3 | 0.3 | |
Zileuton | >100 | >100 | |||
CYP2D6 | Bufuralol 1′-hydroxylation | Quinidine | 0.1 | 0.1 | |
Zileuton | >100 | >100 | |||
CYP3A4 | Testosterone 6β-hydroxylation | Ketoconazole | 0.02 | 0.05 | |
Zileuton | >100 | >100 | |||
CYP2B6 | Bupropion hydroxylation | N-(α-Methylbenzyl)-1-aminobenzotriazole | 0.03 | 0.05 | |
Zileuton | >100 | >100 | |||
CYP2E1 | Chlorzoxazone 6-hydroxylation | 4-Methylpyrazole | 3.0 | 1.79 | |
|
| Zileuton | >100 | >100 |