TABLE 1

Comparison of AUC_{0-30 min}between control and different inhibitors in isolated perfused rat livers

	Control	Troleandomycin	GG918	Cyclosporine
Tacrolimus
AUC (ng/ml · min)^a	2,260 ± 430	5,200 ± 2,470^*	1,730 ± 270^*	4,390 ± 2,080^*
AUC_M (ng/ml · min)^a	22,900 ± 10,900	72,100 ± 7,900^*	12,100 ± 4,500	70,200 ± 27,200^*
AUC_M/AUC^b	9.35 ± 1.94	10.3 ± 2.4	6.24 ± 1.74	11.9 ± 2.1
Felodipine
AUC (ng/ml · min)	4,380 ± 320	6,150 ± 900^*	4,000 ± 50	5,310 ± 950
AUC_M^c	693 ± 38	3,120 ± 890^*	1,190 ± 110^*	1,520 ± 670
AUC_M/AUC^c	0.158 ± 0.007	0.504 ± 0.116^*	0.297 ± 0.024^*	0.285 ± 0.116^*

↵* Significantly different from control, P < 0.05
↵ a AUC_{0-30 min} (noncompartmental model) of parent (AUC) and metabolite (AUC_M).
↵ b Tacrolimus metabolite measured by UV/MS response factor.
↵ c Felodipine metabolite peak area measured by MS, arbitrary unit.