Plasma pharmacokinetic parameters of LY293111 and total radioactivity in F344 rats after oral or intravenous administration of [14C] LY293111 sodium
Parameters were calculated from the mean value of three to four samples per time point.
Parameter | Dose | LY293111 | Total 14C |
|---|---|---|---|
| mg/kg | |||
| Cmax (μg/ml or μg-Eq/ml) | 10 i.v. | 11.3 | 12.4 |
| 30 p.o. | 2.8 | 4.9 | |
| t½ (h) | 10 i.v. | 4.4 | 68 |
| 30 p.o. | 2.6 | 50.1 | |
| AUC0-∞ (μg · h/ml or μg-Eq · h/ml) | 10 i.v. | 22.1 | 41 |
| 30 p.o. | 15.2 | 30.8 | |
| Oral bioavailability | 30 p.o. | 22.9% | 25.0% |
Cmax, maximal plasma concentration; t½, apparent elimination half-life; AUC0-∞, area under the plasma concentration vs. time curve from 0 h to infinity.