[14C]LY293111 metabolites (percentage of total dose) in 0- to 24-h samples of bile and feces of F344 rats after a single 30 mg/kg oral dose of [14C]LY293111 sodium
Values for 0- to 24-h bile were obtained by combining results from 0- to 6-, 6- to 12-, 12- to 18-, and 18- to 24-h bile samples for each rat.
Peak | Metabolite Identification | Percentage of Total Dose | ||||
|---|---|---|---|---|---|---|
| Feces | Bile | Total a | ||||
| P | LY293111 | 33 | 0.5 | 34 | ||
| M2 | Acyl glucuronide | 0 | 16 | 16 | ||
| M4 | Parent + O-glucuronide | 0 | 0.1 | 0.1 | ||
| M7 | Ether glucuronide | 0 | 20 | 20 | ||
| M9 | bis-Glucuronide | 0 | 14 | 14 | ||
| M10 | Parent + O-bis-glucuronide | 0 | 0.3 | 0.3 | ||
| M12 | M11 glucuronide | 0 | 0.2 | 0.2 | ||
|
| Total | 33 | 51 | 85 | ||
↵ a Percentages corrected for column recovery and extraction efficiency.