TABLE 6

LC/MS data for metabolites of LY293111

Peak
[M + NH4+]/[M + H]+
Retention Time a
Characteristic Product Ions
min m/z
LY293111 562/545 b 46.9 ms/ms of 545: 527,313,295,273,255, 245,217,213
M1 738/na 45.9 ms/ms of 738: 703,545,527,471,295,255,245
M2 738/na 44.4 ms/ms of 738: 703,562,545,527,449,313,295,273,255,245,217
M3 578/561 43.8 ms/ms of 578: 543,329,311,273,271,229
M4 754/na 43.0 ms/ms of 754: 561,543,329,311,271,273
M5 na/561 c 36.6 ms/ms of 525 (base peak in MS APCI): 497,483,467,313,295,271,255,243,213
M6 na/561 c 34.3 ms/ms of 543 (base peak in MS APCI) 497,483,467,313,295,271,255,243,213
M8 914/na 31.7 ms/ms of 914:879,703,545,527
M7 738/na 31.3 ms/ms of 738: 703,545,527,313,295,273,255,245
M9 914/na 30.2 ms/ms of 914: 738,605,545,527,295,273,255
M10 930/na 29.2 ms/ms of 754 561,543,329,311
M11 na/273 16.5 ms/ms of 273: 255,213
(base peak)
M12
466/na
5.7
ms/ms of 466: 273,255,213

  • na, not observed.

  • ↵ a Retention times and product ions are based on 24-h rat slice data.

  • ↵ b Underlined ions are base peak ions.

  • ↵ c APCI gave protonated molecular ions.