TABLE 2

Changes in tissue (+)-AMP to (+)-METH AUC molar ratios in control and mAb-treated rats.

Tissue	Molar Ratio of (+)-AMP to (+)-METH AUC₀^4.5^h^a
Tissue		Control ^b	Anti-(+)-METH mAb ^c
Total serum	0.34	0.01
Unbound serum		0.38
Brain	0.32	0.36
Liver	0.39	0.10
Testis	0.27	0.13
Kidney	0.31	0.28
Spleen	0.34	0.18

↵ a The molar ratio of (+)-AMP to (+)-METH AUC was calculated by dividing the nmol · h/g or nmol · h/ml AUC₀^4.5^h values.
↵ b Control rats were treated with vehicle 17 h before a 1 mg/kg i.v. (+)-METH dose.
↵ c Rats were treated with anti-(+)-METH mAb6H4 17 h before a 1 mg/kg i.v. (+)-METH dose.