TABLE 3

Molecular and product ions observed for garenoxacin and its metabolites by LC/MS/MS

Compounda
Retention Time
(M + H)+
Product Ions
min m/z
Garenoxacin 23.7 427 366, 326, 305, 298, 286
Sulfate conjugate (T-3811M1) 29.1 505b 461b
Carbamoyl glucuronide (M2) 27.8 647 629, 471, 453
Carbamic acid (M3) 35.4 471 453
Oxidative product (T-3811M4) 38.1 441 423
Oxidative product (T-3811M5) 30.3 457 439, 382
Acyl glucuronide (M6)
11.7
603
586, 427, 366

  • ↵ a Authentic compounds synthesized or code numbers of metabolites are indicated in parentheses.

  • ↵ b The values were obtained as (M - H).