Plasma pharmacokinetic parameter estimates for ISIS 104838 after i.v. bolus administration and compared across species
Standard error of the estimate values are shown in parentheses.
Parameter | Mouse (5 mg/kg) | Rata (5 mg/kg) | Dog (2 mg/kg) | Monkey (2 mg/kg) |
|---|---|---|---|---|
| A (μg/ml) | 37.1 (13.0) | 43.5 (3.12) | 31.1 (1.1) | 36.1 (6.3) |
| B (μg/ml) | 0.9 (0.7) | 3.5 (1.5) | ||
| C (μg/ml) | 0.4 (0.3) | |||
| t1/2α (h) | 0.097 (0.024) | 0.25 (0.03) | 0.37 (0.01) | 0.37 (0.01) |
| t1/2β (h) | 0.79 (0.47) | 1.9 (1.2) | ||
| t1/2γ (h) | 11.1 (8.8) | |||
| Co (μg/ml) | 37.9 (13.2) | 47.4 (3.4) | 31.1 (1.1) | 36.1 (2.6) |
| AUC (μg · h/ml) | 6.2 (1.2) | 32.1 (2.5) | 16.7 (0.7) | 20.7 (0.6) |
| CL (ml/h/kg) | 809 (153) | 93.6 (7.2) | 121 (4.9) | 97.1 (2.6) |
| Vss (ml/kg) | 242 (103) | 413 (243) | 64.7 (2.4) | 57.3 (3.0) |
| t1/2K10 (h) | 0.11 (0.03) | 0.47 (0.05) | 0.37 (0.01) | 0.37 (0.01) |
Co, plasma concentration at time 0, immediately after i.v. bolus injection.
↵ a Radiolabel data (uses μg-Eq of [3H]ISIS 104838).