Effect of length of oligonucleotide (ISIS 104838 and metabolites) on protein binding in whole human plasma
Sequence | Length | Concentration | %Fbound |
|---|---|---|---|
| μM | |||
| 5′ GCTGATTAGAGAGAGGTCCC 3′ | 20 | 0.1 | 98.15 ± 0.10 |
| 10 | 96.99 ± 0.13 | ||
| 5′ GCTGATTAGAG 3′ | 11 | 0.1 | 80.83 ± 0.39 |
| 10 | 75.30 ± 0.72 | ||
| 5′ GCTGATTAGA 3′ | 10 | 0.1 | 89.73 ± 0.49 |
| 10 | 84.59 ± 0.88 | ||
| 5′ GCTGATTAG 3′ | 9 | 0.1 | 81.54 ± 0.51 |
| 10 | 77.52 ± 0.60 | ||
| 5′ GCTGATTA 3′ | 8 | 0.1 | 79.61 ± 1.00 |
|
|
| 10 | 70.95 ± 1.45 |