TABLE 1

Major metabolites of I in urine and bile of rats after i.v. administration of 14C-labeled I at a 5 mg/kg dose (n = 3).

The listed retention times are from the HPLC method used for metabolite profiling (detailed under Materials and Methods)


Metabolite

tR

Urine

Bile
min % dose % dose
M1 11.7 18 28
M2 13.5 N.D. 38
M3 16.4 N.D. 2
I
23.5
N.D.
1
  • N.D., not detected