TABLE 1

Noncompartmental pharmacokinetic parameters for total radioactivity, EP, and EPA after oral administration of [14C] EP

Parameter a
Total Radioactivity b
EP Plasma
EPA Plasma
Blood
Saliva
Plasma
Cmax (μg/ml) 1.77 ± 0.23 2.17 ± 0.79 c 2.49 ± 0.31 1.72 ± 0.28 0.083 ± 0.017
Tmax (h) 1.2 ± 0.6 0.6 ± 0.3 c 1.3 ± 0.6 1.3 ± 0.8 1.1 ± 0.3
AUC (μg · h/ml)
12.8 ± 2.3
7.96 ± 1.41
18.4 ± 3.4
9.54 ± 3.20
0.352 ± 0.115

  • ↵ a Mean of eight subjects ± standard deviation of the mean.

  • ↵ b Mass units for total radioactivity are expressed in μg Eq.

  • ↵ c Parameter was predominantly influenced by residual radioactivity in the mouth following oral administration of radioactive dose solution.