TABLE 2

Pharmacokinetic parameters of EP and EPA after oral administration to humans

Parameter a
Subject 1
Subject 2
Subject 3
Subject 4
Subject 5
Subject 6
Subject 7
Subject 8
Mean
S.D.
k20 (h−1) 1.82 5.66 0.994 2.32 2.49 11.28 3.90 2.66 3.89 3.31
k12 (h−1) 0.242 0.283 0.193 0.169 0.259 0.229 0.325 0.214 0.239 0.045
k23 (h−1) 0.075 0.197 0.068 0.172 0.133 0.456 0.175 0.149 0.178 0.122
k24 (h−1) 0.030 0.078 0.020 0.037 0.046 0.223 0.053 0.057 0.068 0.065
k35 (h−1) 18.7 1.46 6.68 18.5 9.76 11.31 17.5 16.0 12.5 6.28
k (h−1) b 1.92 5.94 1.08 2.53 2.67 12.0 4.13 2.87 4.14 3.48
t½ - k12 (h) 2.86 2.45 3.59 4.10 2.68 3.03 2.13 3.24 3.01 0.63
t½ - k (h) b 0.36 0.12 0.64 0.27 0.26 0.058 0.17 0.24 0.26 0.18
V1/F (liters) 6.63 2.63 7.53 2.49 4.27 0.95 3.87 3.82 4.02 2.17
V2/F (liters)
0.702
4.94
1.87
0.567
1.75
1.05
0.836
0.662
1.55
1.46

  • ↵ a Rate constants are defined in Fig. 2. V1 and V2 are volume of distribution of EP and EPA, respectively.

  • ↵ b k = k20 + k23 + k24.