TABLE 2
Effect of procarbazine and its deuterated analogs on sperm count 18 days after administration of 200 mg/kg procarbazine HCl and equimolar amounts of the deuterated analogs to male BDF2mice ( Yost et al., 1985 )
Structures of Procarbazine and Its Deuterated Analogsa | Sperm Count (% controlb) |
|---|---|
| H H | 65 |
| R′—CH2—N—N—CH3 | |
| H H | 66 |
| R′—CH2—N—N—CD3 | |
| H—H | 99 |
| R′—CD2—N—N—CH3 |
|
