TABLE 3

Effect of deuterium substitution on rat hepatic DNA adduct formation and micronucleus formation in MCL-5 human cells

Drug Structures^a	Hepatic DNA Adducts	Micronuclei
	per 108 nucleotides	per 500 cells
Tamoxifen	11 ± 1	20, 25
Tamoxifen-d₅	4 ± 1	10, 8

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