Effect of delayed gastric emptying and effect of metabolism and secretion on drug absorption
Drug Class | Rate of Absorption | Extent of Absorption |
|---|---|---|
| Acid-labile compounds | ↓ | ↓ |
| Relatively insoluble compounds | ↓ | ↑ |
| Compounds with good water and lipid solubility | ↓ | ↔ |
| Compounds whose absorption is mediated by intestinal transporters | ↓ | ↑ |
| Compounds that are metabolized by intestine | ↓ | |
| Compounds that are effluxed by intestine |
| ↓ |