Table 2

Clopidogrel metabolism by different human P450 isozymes expressed in insect cell microsomes

P450 IsozymeClopidogrel Remaining after 10 minp-Value2-a Compared with BlankRate
μM nmol min−1 nmol P450 −1
Blank50  ± 3.7
1A148  ± 1.10.370
1A245  ± 2.60.04418  ± 9
2A645  ± 3.80.102
2B643  ± 2.20.01523  ± 7
2C949  ± 1.30.796
2C1949  ± 1.50.524
2D647  ± 2.30.210
2E145  ± 4.10.083
3A422  ± 4.20.000193  ± 14
3A532  ± 7.30.000358  ± 24
  • 2-a  The results were compared using an unpaired t test with a value of <0.05 considered significant. The experiments were performed as described underExperimental Procedures.