Kinetic parameters for NE-100 metabolic activity in human liver and intestinal microsomes
| K m1 | K m2 | V max1 | V max2 | CLint | |
| μM | nmol/min/mg protein | ml/min/mg protein | |||
| Liver | 0.059 | 3.087 | 0.089 | 0.715 | 1.728 |
| K m | V max | CLint | |||
| μM | nmol/min/mg protein | ml/min/mg protein | |||
| Intestine | 45.890 | 3.130 | 0.068 | ||
For NE-100 metabolism in the liver, Km1 andVmax1 represent apparent affinity constant and apparent maximum metabolic activity for high-affinity components, andKm2 and Vmax2 represent apparent affinity constant and apparent maximum metabolic activity for low-affinity components. CLint in liver was calculated as the sum of the ratio of Vmax to Km in high- and low affinity components based on two enzyme model. For NE-100 metabolism in the intestine, Km andVmax represent apparent affinity component and apparent maximal metabolic activity. CLint in intestine was calculated as the ratio of Vmax toKm.